Hot spot mutations in Finnish non-small cell lung cancers

Highlights • Frequency of known mutations in Finnish NSCLC is similar to Western patients. • KRAS codon 12 mutations are the most common recurrent mutations. • Frequency of BRAF mutations is higher in Finnish NSCLC, although lower for V600E. • STK11 and ERBB2 mutations have lower frequencies in Finn...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-09, Vol.99, p.102-110
Hauptverfasser:	Mäki-Nevala, Satu, Sarhadi, Virinder Kaur, Rönty, Mikko, Kettunen, Eeva, Husgafvel-Pursiainen, Kirsti, Wolff, Henrik, Knuuttila, Aija, Knuutila, Sakari
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Alleles Biomarkers, Tumor Carcinoma, Non-Small-Cell Lung - epidemiology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Child Child, Preschool Female Finland - epidemiology Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genotype Hematology, Oncology and Palliative Medicine High-Throughput Nucleotide Sequencing Humans Lung cancer Lung Neoplasms - epidemiology Lung Neoplasms - genetics Lung Neoplasms - mortality Male Middle Aged Mutation Non-small cell lung cancer Oncogenes Pulmonary/Respiratory Young Adult
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Zusammenfassung:	Highlights • Frequency of known mutations in Finnish NSCLC is similar to Western patients. • KRAS codon 12 mutations are the most common recurrent mutations. • Frequency of BRAF mutations is higher in Finnish NSCLC, although lower for V600E. • STK11 and ERBB2 mutations have lower frequencies in Finnish NSCLC patients. • TP53 mutations occurred often with other mutations ( PIK3CA , EGFR , BRAF , MET , KRAS).
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2016.06.024