Predicting the neurobehavioral side effects of dexamethasone in pediatric acute lymphoblastic leukemia

Highlights • There are no predictors of neuropsychological problems of dexamethasone. • The very low dose dexamethasone suppression test did not predict these problems. • Dexamethasone trough levels did also not influence neuropsychological problems. • Patients with glucocorticoid hypersensitivity h...

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Veröffentlicht in:	Psychoneuroendocrinology 2016-10, Vol.72, p.190-195
Hauptverfasser:	Warris, Lidewij T, van den Akker, Erica L.T, Aarsen, Femke K, Bierings, Marc B, van den Bos, Cor, Tissing, Wim J.E, Sassen, Sebastiaan D.T, Veening, Margreet A, Zwaan, Christian M, Pieters, Rob, van den Heuvel-Eibrink, Marry M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adolescent Adolescent Behavior - drug effects Antineoplastic Agents, Hormonal - adverse effects Child Child Behavior - drug effects Child, Preschool Depression - chemically induced Dexamethasone Dexamethasone - adverse effects Dexamethasone suppression test Endocrinology & Metabolism Female Humans Hydrocortisone - metabolism Male Neurobehavioral problems Pediatrics Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Predictive Value of Tests Predictors Problem Behavior Psychiatry Sleep Wake Disorders - chemically induced
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Zusammenfassung:	Highlights • There are no predictors of neuropsychological problems of dexamethasone. • The very low dose dexamethasone suppression test did not predict these problems. • Dexamethasone trough levels did also not influence neuropsychological problems. • Patients with glucocorticoid hypersensitivity had more depressive symptoms. • The role of glucocorticoid sensitivity in these problems should be unraveled.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2016.07.006