Genetic and environmental modulation of neurodevelopmental disorders: translational insights from labs to beds
Highlights • Neurodevelopmental disorders (NDDs) are severely debilitating neuropsychiatric illnesses. • NDDs are caused by aberrant brain development, and have strong genetic causes and risk factors. • NDDs are also modulated by various environmental factors, and can be modeled experimentally. • An...
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| Veröffentlicht in: | Brain research bulletin 2016-07, Vol.125, p.79-91 |
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| creator | Homberg, Judith R Kyzar, Evan J Scattoni, Maria Luisa Norton, William H Pittman, Julian Gaikwad, Siddharth Nguyen, Michael Poudel, Manoj K Ullmann, Jeremy F.P Diamond, David M Kaluyeva, Aleksandra A Parker, Matthew O Brown, Richard E Song, Cai Gainetdinov, Raul R Gottesman, Irving I Kalueff, Allan V |
| description | Highlights • Neurodevelopmental disorders (NDDs) are severely debilitating neuropsychiatric illnesses. • NDDs are caused by aberrant brain development, and have strong genetic causes and risk factors. • NDDs are also modulated by various environmental factors, and can be modeled experimentally. • Animal models are a valuable tool to mimic a wide spectrum of NDDs and related conditions. • Here, we discuss the neurobiological mechanisms of selected NDDs and their experimental models. |
| doi_str_mv | 10.1016/j.brainresbull.2016.04.015 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Advisory Committees - standards Animals Environment Experimental model Genetic Therapy - methods Humans Model organism Neurodevelopmental disorder Neurodevelopmental Disorders - genetics Neurodevelopmental Disorders - psychology Neurodevelopmental Disorders - therapy Neurology Preclinical study Translational Medical Research Translational research |
| title | Genetic and environmental modulation of neurodevelopmental disorders: translational insights from labs to beds |
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