Genetic and environmental modulation of neurodevelopmental disorders: translational insights from labs to beds

Highlights • Neurodevelopmental disorders (NDDs) are severely debilitating neuropsychiatric illnesses. • NDDs are caused by aberrant brain development, and have strong genetic causes and risk factors. • NDDs are also modulated by various environmental factors, and can be modeled experimentally. • An...

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Veröffentlicht in:	Brain research bulletin 2016-07, Vol.125, p.79-91
Hauptverfasser:	Homberg, Judith R, Kyzar, Evan J, Scattoni, Maria Luisa, Norton, William H, Pittman, Julian, Gaikwad, Siddharth, Nguyen, Michael, Poudel, Manoj K, Ullmann, Jeremy F.P, Diamond, David M, Kaluyeva, Aleksandra A, Parker, Matthew O, Brown, Richard E, Song, Cai, Gainetdinov, Raul R, Gottesman, Irving I, Kalueff, Allan V
Format:	Artikel
Sprache:	eng
Schlagworte:	Advisory Committees - standards Animals Environment Experimental model Genetic Therapy - methods Humans Model organism Neurodevelopmental disorder Neurodevelopmental Disorders - genetics Neurodevelopmental Disorders - psychology Neurodevelopmental Disorders - therapy Neurology Preclinical study Translational Medical Research Translational research
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Zusammenfassung:	Highlights • Neurodevelopmental disorders (NDDs) are severely debilitating neuropsychiatric illnesses. • NDDs are caused by aberrant brain development, and have strong genetic causes and risk factors. • NDDs are also modulated by various environmental factors, and can be modeled experimentally. • Animal models are a valuable tool to mimic a wide spectrum of NDDs and related conditions. • Here, we discuss the neurobiological mechanisms of selected NDDs and their experimental models.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2016.04.015