Effect of magnesium sulfate on MMP-9 and AQP-9 protein in placenta of patients with hypertensive disorders complicating pregnancy

To investigate the protein content and protein expression of MMP-9 and AQP-9 in the placenta of patients with hypertensive disorders complicating pregnancy.And to investigate the mechanism of magnesium sulfate in the treatment of hypertensive disorders complicating pregnancy. The patients with hypertensive disorders complicating pregnancy were divided into treatment group (n=51) and untreated group (n=45), and 20 cases of normal pregnant women were selected as the control group. The three groups were taken from the placenta after delivery. ELISA and immunohistochemistry method were used to detect the protein content and protein expression of AQP-9 and MMP-9 in placenta of each group. The protein contents and protein expression of MMP-9 in placenta tissues of treatment group were 5.89±0.52 and 125.2±0.5; AQP-9's were 4.3±0.5 and 110±4. The protein contents and protein expression of MMP-9 in placenta tissues of untreated group were 1.85±0.26 and 148.6±5.2; AQP-9's were 9.4±0.8 and 92±3. The protein contents and