Inducible nitric oxide inhibitor aminoguanidine, ameliorates deleterious effects of lipopolysaccharide on memory and long term potentiation in rat

An interaction between nitric oxide (NO) and neuro-inflammation has been considered to modulate learning and memory. In the present study, the effect of an inducible NO synthase (iNOS) inhibitor, aminoguanidine (AG) on lipopolysaccharide (LPS)-induced memory impairment was evaluated. The rats were d...

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Veröffentlicht in:	Life sciences (1973) 2016-08, Vol.158, p.22-30
Hauptverfasser:	Anaeigoudari, Akbar, Soukhtanloo, Mohammad, Reisi, Parham, Beheshti, Farimah, Hosseini, Mahmoud
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoguanidine Animals Enzyme Inhibitors - pharmacology Excitatory Postsynaptic Potentials Guanidines - pharmacology Hippocampus - metabolism Inducible nitric oxide Learning Lipopolysaccharide Lipopolysaccharides - pharmacology Long-Term Potentiation - drug effects LTP Male Malondialdehyde - metabolism Memory Memory - drug effects Nitric Oxide Synthase Type II - antagonists & inhibitors Rats Rats, Wistar
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Zusammenfassung:	An interaction between nitric oxide (NO) and neuro-inflammation has been considered to modulate learning and memory. In the present study, the effect of an inducible NO synthase (iNOS) inhibitor, aminoguanidine (AG) on lipopolysaccharide (LPS)-induced memory impairment was evaluated. The rats were divided and treated: Control (Saline), LPS, AG - LPS and AG, before behavioral and electrophysiological experiments. The escape latency in Morris water maze (MWM) test and the latency to enter the dark compartment in Passive avoidance (PA) test in LPS group were significantly higher than in control (P
ISSN:	0024-3205 1879-0631
DOI:	10.1016/j.lfs.2016.06.019