Low-dose lithium adjunct therapy associated with reduced off-time in Parkinson's disease: A case series

Highlights • Low dose lithium adjunct therapy may reduce off-time in Parkinson's disease (PD). • Low-dose, unlike standard-dose, adjunct lithium did not increase dyskinesias in PD. • Low-dose lithium was poorly tolerated in the 2 PD patients with dementia. • A placebo-controlled trial is needed...

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Veröffentlicht in:	Journal of the neurological sciences 2016-09, Vol.368, p.221-222
1. Verfasser:	Guttuso, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antiparkinson Agents - therapeutic use Dyskinesias Female Follow-Up Studies Humans Levodopa - therapeutic use Lithium Lithium Chloride - therapeutic use Male Middle Aged Motor fluctuations Neurology Off-time Parkinson Disease - drug therapy Parkinson's disease
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Zusammenfassung:	Highlights • Low dose lithium adjunct therapy may reduce off-time in Parkinson's disease (PD). • Low-dose, unlike standard-dose, adjunct lithium did not increase dyskinesias in PD. • Low-dose lithium was poorly tolerated in the 2 PD patients with dementia. • A placebo-controlled trial is needed to properly assess low-dose lithium's effects on off-time.
ISSN:	0022-510X 1878-5883
DOI:	10.1016/j.jns.2016.07.027