Prevalence and drug resistance pattern of MDR TB in retreatment cases of Punjab, Pakistan
To determine the prevalence and resistance pattern of multidrug-resistant tuberculosis. This cross-sectional study was carried out from January 2010 to June 2014 in nine tertiary care hospitals implementing programmatic management of drug-resistant tuberculosis in Punjab, and comprised retreatment t...
Gespeichert in:
| Veröffentlicht in: | Journal of the Pakistan Medical Association 2016-08, Vol.66 (8), p.989-993 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 993 |
|---|---|
| container_issue | 8 |
| container_start_page | 989 |
| container_title | Journal of the Pakistan Medical Association |
| container_volume | 66 |
| creator | Akhtar, Abdul Majeed Arif, Muhammad Awais Kanwal, Shamsa Majeed, Sadia |
| description | To determine the prevalence and resistance pattern of multidrug-resistant tuberculosis.
This cross-sectional study was carried out from January 2010 to June 2014 in nine tertiary care hospitals implementing programmatic management of drug-resistant tuberculosis in Punjab, and comprised retreatment tuberculosis cases. Data was collected from the Electronic Nominal Review System. SPSS 17 was used for data analysis.
Of the 1,250 cases, 861(69%) were of multidrug-resistant tuberculosis confirmed through drug sensitivity testing. The mean age was 32 (±13.5 SD) years. Besides, 664(53%) were males and 1,208(97%) resided in urban areas of Punjab. Multidrug-resistant tuberculosis was found to be more prevalent in the most productive age group, i.e. 15-45 years, with 709(57%) cases (p |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1812881990</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A461381847</galeid><sourcerecordid>A461381847</sourcerecordid><originalsourceid>FETCH-LOGICAL-g309t-384a284bbff51867812e2596dd1e0b2a6dce712c19696b8df3a8126622e3a103</originalsourceid><addsrcrecordid>eNptkU1Lw0AQhnNQbK3-BVkQxIOR_Ui2m2Otn1CxSC-ewiSZtFuTTd3dCP57E1vBgsxh4H2fd5hhDoIhpYKGSaL4IDh2bk0plzGlR8GAj2MexSIaBm9zi59QocmRgClIYdslsei089BrG_AerSFNSZ5vX8nihmjT-d4i-BqNJzk4dL09b80asisyh_ef8ElwWELl8HTXR8Hi_m4xfQxnLw9P08ksXAqa-FCoCLiKsqwsY6bkWDGOPE5kUTCkGQdZ5DhmPGeJTGSmilJAh0jJOQpgVIyCy-3YjW0-WnQ-rbXLsarAYNO6lHW0UixJevR8iy67g1NtysZbyHs8nUSSCcVUNO6o63-orgqsdd4YLHWn7wUu_gRWCJVfuaZqvW6M2wfPdqu2WY1FurG6BvuV_n5DfAO384Fv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1812881990</pqid></control><display><type>article</type><title>Prevalence and drug resistance pattern of MDR TB in retreatment cases of Punjab, Pakistan</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Akhtar, Abdul Majeed ; Arif, Muhammad Awais ; Kanwal, Shamsa ; Majeed, Sadia</creator><creatorcontrib>Akhtar, Abdul Majeed ; Arif, Muhammad Awais ; Kanwal, Shamsa ; Majeed, Sadia</creatorcontrib><description>To determine the prevalence and resistance pattern of multidrug-resistant tuberculosis.
This cross-sectional study was carried out from January 2010 to June 2014 in nine tertiary care hospitals implementing programmatic management of drug-resistant tuberculosis in Punjab, and comprised retreatment tuberculosis cases. Data was collected from the Electronic Nominal Review System. SPSS 17 was used for data analysis.
Of the 1,250 cases, 861(69%) were of multidrug-resistant tuberculosis confirmed through drug sensitivity testing. The mean age was 32 (±13.5 SD) years. Besides, 664(53%) were males and 1,208(97%) resided in urban areas of Punjab. Multidrug-resistant tuberculosis was found to be more prevalent in the most productive age group, i.e. 15-45 years, with 709(57%) cases (p<0.05), in urban areas1, 208(97%) cases (p<0.05) and in the pulmonary site 852(68%) cases (p<0.05). Overall, 391(41%) cases showed resistance to all first-line anti-tuberculosis drugs while 239(28%) showed resistance to oral first-line drugs. Besides, 526(42%) cases showed resistance to fluoroquinolones and 650(52%) to second-line drugs. Of them, 420(81%), (p<0.05) patients showed highly significant resistance to fluoroquinolones and 26(5%) to ethionamide.
There is a need to fully implement national tuberculosis guidelines with a focus on expansion and effective implementation of directly observed therapy short course in order to prevent further emergence of drug resistance.</description><identifier>ISSN: 0030-9982</identifier><identifier>PMID: 27524534</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Adolescent ; Adult ; Analysis ; Antitubercular agents ; Antitubercular Agents - therapeutic use ; Child ; Child, Preschool ; Cross-Sectional Studies ; Drug Resistance, Multiple, Bacterial ; Drug therapy ; Ethionamide ; Female ; Fluoroquinolones ; Humans ; Infant ; Infant, Newborn ; Male ; Microbial drug resistance ; Microbial Sensitivity Tests ; Middle Aged ; Mycobacterium tuberculosis - physiology ; Pakistan - epidemiology ; Prevalence ; Retreatment ; Tuberculosis ; Tuberculosis, Multidrug-Resistant - drug therapy ; Tuberculosis, Multidrug-Resistant - epidemiology ; Young Adult</subject><ispartof>Journal of the Pakistan Medical Association, 2016-08, Vol.66 (8), p.989-993</ispartof><rights>COPYRIGHT 2016 Knowledge Bylanes</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27524534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akhtar, Abdul Majeed</creatorcontrib><creatorcontrib>Arif, Muhammad Awais</creatorcontrib><creatorcontrib>Kanwal, Shamsa</creatorcontrib><creatorcontrib>Majeed, Sadia</creatorcontrib><title>Prevalence and drug resistance pattern of MDR TB in retreatment cases of Punjab, Pakistan</title><title>Journal of the Pakistan Medical Association</title><addtitle>J Pak Med Assoc</addtitle><description>To determine the prevalence and resistance pattern of multidrug-resistant tuberculosis.
This cross-sectional study was carried out from January 2010 to June 2014 in nine tertiary care hospitals implementing programmatic management of drug-resistant tuberculosis in Punjab, and comprised retreatment tuberculosis cases. Data was collected from the Electronic Nominal Review System. SPSS 17 was used for data analysis.
Of the 1,250 cases, 861(69%) were of multidrug-resistant tuberculosis confirmed through drug sensitivity testing. The mean age was 32 (±13.5 SD) years. Besides, 664(53%) were males and 1,208(97%) resided in urban areas of Punjab. Multidrug-resistant tuberculosis was found to be more prevalent in the most productive age group, i.e. 15-45 years, with 709(57%) cases (p<0.05), in urban areas1, 208(97%) cases (p<0.05) and in the pulmonary site 852(68%) cases (p<0.05). Overall, 391(41%) cases showed resistance to all first-line anti-tuberculosis drugs while 239(28%) showed resistance to oral first-line drugs. Besides, 526(42%) cases showed resistance to fluoroquinolones and 650(52%) to second-line drugs. Of them, 420(81%), (p<0.05) patients showed highly significant resistance to fluoroquinolones and 26(5%) to ethionamide.
There is a need to fully implement national tuberculosis guidelines with a focus on expansion and effective implementation of directly observed therapy short course in order to prevent further emergence of drug resistance.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis</subject><subject>Antitubercular agents</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Drug therapy</subject><subject>Ethionamide</subject><subject>Female</subject><subject>Fluoroquinolones</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Microbial drug resistance</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis - physiology</subject><subject>Pakistan - epidemiology</subject><subject>Prevalence</subject><subject>Retreatment</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Multidrug-Resistant - drug therapy</subject><subject>Tuberculosis, Multidrug-Resistant - epidemiology</subject><subject>Young Adult</subject><issn>0030-9982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU1Lw0AQhnNQbK3-BVkQxIOR_Ui2m2Otn1CxSC-ewiSZtFuTTd3dCP57E1vBgsxh4H2fd5hhDoIhpYKGSaL4IDh2bk0plzGlR8GAj2MexSIaBm9zi59QocmRgClIYdslsei089BrG_AerSFNSZ5vX8nihmjT-d4i-BqNJzk4dL09b80asisyh_ef8ElwWELl8HTXR8Hi_m4xfQxnLw9P08ksXAqa-FCoCLiKsqwsY6bkWDGOPE5kUTCkGQdZ5DhmPGeJTGSmilJAh0jJOQpgVIyCy-3YjW0-WnQ-rbXLsarAYNO6lHW0UixJevR8iy67g1NtysZbyHs8nUSSCcVUNO6o63-orgqsdd4YLHWn7wUu_gRWCJVfuaZqvW6M2wfPdqu2WY1FurG6BvuV_n5DfAO384Fv</recordid><startdate>20160831</startdate><enddate>20160831</enddate><creator>Akhtar, Abdul Majeed</creator><creator>Arif, Muhammad Awais</creator><creator>Kanwal, Shamsa</creator><creator>Majeed, Sadia</creator><general>Knowledge Bylanes</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20160831</creationdate><title>Prevalence and drug resistance pattern of MDR TB in retreatment cases of Punjab, Pakistan</title><author>Akhtar, Abdul Majeed ; Arif, Muhammad Awais ; Kanwal, Shamsa ; Majeed, Sadia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g309t-384a284bbff51867812e2596dd1e0b2a6dce712c19696b8df3a8126622e3a103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis</topic><topic>Antitubercular agents</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Drug therapy</topic><topic>Ethionamide</topic><topic>Female</topic><topic>Fluoroquinolones</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Microbial drug resistance</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Mycobacterium tuberculosis - physiology</topic><topic>Pakistan - epidemiology</topic><topic>Prevalence</topic><topic>Retreatment</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Multidrug-Resistant - drug therapy</topic><topic>Tuberculosis, Multidrug-Resistant - epidemiology</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Akhtar, Abdul Majeed</creatorcontrib><creatorcontrib>Arif, Muhammad Awais</creatorcontrib><creatorcontrib>Kanwal, Shamsa</creatorcontrib><creatorcontrib>Majeed, Sadia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Pakistan Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akhtar, Abdul Majeed</au><au>Arif, Muhammad Awais</au><au>Kanwal, Shamsa</au><au>Majeed, Sadia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and drug resistance pattern of MDR TB in retreatment cases of Punjab, Pakistan</atitle><jtitle>Journal of the Pakistan Medical Association</jtitle><addtitle>J Pak Med Assoc</addtitle><date>2016-08-31</date><risdate>2016</risdate><volume>66</volume><issue>8</issue><spage>989</spage><epage>993</epage><pages>989-993</pages><issn>0030-9982</issn><abstract>To determine the prevalence and resistance pattern of multidrug-resistant tuberculosis.
This cross-sectional study was carried out from January 2010 to June 2014 in nine tertiary care hospitals implementing programmatic management of drug-resistant tuberculosis in Punjab, and comprised retreatment tuberculosis cases. Data was collected from the Electronic Nominal Review System. SPSS 17 was used for data analysis.
Of the 1,250 cases, 861(69%) were of multidrug-resistant tuberculosis confirmed through drug sensitivity testing. The mean age was 32 (±13.5 SD) years. Besides, 664(53%) were males and 1,208(97%) resided in urban areas of Punjab. Multidrug-resistant tuberculosis was found to be more prevalent in the most productive age group, i.e. 15-45 years, with 709(57%) cases (p<0.05), in urban areas1, 208(97%) cases (p<0.05) and in the pulmonary site 852(68%) cases (p<0.05). Overall, 391(41%) cases showed resistance to all first-line anti-tuberculosis drugs while 239(28%) showed resistance to oral first-line drugs. Besides, 526(42%) cases showed resistance to fluoroquinolones and 650(52%) to second-line drugs. Of them, 420(81%), (p<0.05) patients showed highly significant resistance to fluoroquinolones and 26(5%) to ethionamide.
There is a need to fully implement national tuberculosis guidelines with a focus on expansion and effective implementation of directly observed therapy short course in order to prevent further emergence of drug resistance.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>27524534</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0030-9982 |
| ispartof | Journal of the Pakistan Medical Association, 2016-08, Vol.66 (8), p.989-993 |
| issn | 0030-9982 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1812881990 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Analysis Antitubercular agents Antitubercular Agents - therapeutic use Child Child, Preschool Cross-Sectional Studies Drug Resistance, Multiple, Bacterial Drug therapy Ethionamide Female Fluoroquinolones Humans Infant Infant, Newborn Male Microbial drug resistance Microbial Sensitivity Tests Middle Aged Mycobacterium tuberculosis - physiology Pakistan - epidemiology Prevalence Retreatment Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - epidemiology Young Adult |
| title | Prevalence and drug resistance pattern of MDR TB in retreatment cases of Punjab, Pakistan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T09%3A48%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20and%20drug%20resistance%20pattern%20of%20MDR%20TB%20in%20retreatment%20cases%20of%20Punjab,%20Pakistan&rft.jtitle=Journal%20of%20the%20Pakistan%20Medical%20Association&rft.au=Akhtar,%20Abdul%20Majeed&rft.date=2016-08-31&rft.volume=66&rft.issue=8&rft.spage=989&rft.epage=993&rft.pages=989-993&rft.issn=0030-9982&rft_id=info:doi/&rft_dat=%3Cgale_proqu%3EA461381847%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1812881990&rft_id=info:pmid/27524534&rft_galeid=A461381847&rfr_iscdi=true |