The mechanism of action of DNA photolyases
Structural analysis, biochemistry and model studies have provided new insights into the mechanism of action of photolyases. The light-driven electron and energy transfer events that lead to the photolyase-catalyzed repair of lethal, mutagenic and carcinogenic UV-light-induced DNA lesions have all be...
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| Veröffentlicht in: | Current Opinion in Chemical Biology 2001-10, Vol.5 (5), p.491-498 |
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| container_end_page | 498 |
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| container_issue | 5 |
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| container_title | Current Opinion in Chemical Biology |
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| creator | Carell, Thomas Burgdorf, Lars T Kundu, Lal Mohan Cichon, Michaela |
| description | Structural analysis, biochemistry and model studies have provided new insights into the mechanism of action of photolyases. The light-driven electron and energy transfer events that lead to the photolyase-catalyzed repair of lethal, mutagenic and carcinogenic UV-light-induced DNA lesions have all been examined in the past few years. |
| doi_str_mv | 10.1016/S1367-5931(00)00239-8 |
| format | Article |
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| ispartof | Current Opinion in Chemical Biology, 2001-10, Vol.5 (5), p.491-498 |
| issn | 1367-5931 1879-0402 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | (6-4) photolyase Carcinogens Catalysis CPD Deoxyribodipyrimidine Photo-Lyase - chemistry Deoxyribodipyrimidine Photo-Lyase - physiology dimer lesion DNA - metabolism DNA Damage - radiation effects DNA photolyase DNA Repair Electron transfer energy transfer Humans Light Molecular Structure Mutation - radiation effects Oxidation-Reduction photoactivation Pyrimidine Dimers - metabolism Substrate Specificity |
| title | The mechanism of action of DNA photolyases |
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