The mechanism of action of DNA photolyases

Structural analysis, biochemistry and model studies have provided new insights into the mechanism of action of photolyases. The light-driven electron and energy transfer events that lead to the photolyase-catalyzed repair of lethal, mutagenic and carcinogenic UV-light-induced DNA lesions have all be...

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Veröffentlicht in:	Current Opinion in Chemical Biology 2001-10, Vol.5 (5), p.491-498
Hauptverfasser:	Carell, Thomas, Burgdorf, Lars T, Kundu, Lal Mohan, Cichon, Michaela
Format:	Artikel
Sprache:	eng
Schlagworte:	(6-4) photolyase Carcinogens Catalysis CPD Deoxyribodipyrimidine Photo-Lyase - chemistry Deoxyribodipyrimidine Photo-Lyase - physiology dimer lesion DNA - metabolism DNA Damage - radiation effects DNA photolyase DNA Repair Electron transfer energy transfer Humans Light Molecular Structure Mutation - radiation effects Oxidation-Reduction photoactivation Pyrimidine Dimers - metabolism Substrate Specificity
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Beschreibung
Zusammenfassung:	Structural analysis, biochemistry and model studies have provided new insights into the mechanism of action of photolyases. The light-driven electron and energy transfer events that lead to the photolyase-catalyzed repair of lethal, mutagenic and carcinogenic UV-light-induced DNA lesions have all been examined in the past few years.
ISSN:	1367-5931 1879-0402
DOI:	10.1016/S1367-5931(00)00239-8