Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid

We report the first case of granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid (ATRA) in a patient with acute promyelocytic leukemia (APL). Acute renal failure during treatment with ATRA has been previously reported as a part of an ATRA syndrome or a thrombotic complicatio...

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Veröffentlicht in:	Anti-cancer drugs 2001-09, Vol.12 (8), p.677-680
Hauptverfasser:	Tomita, Naoto, Kanamori, Heiwa, Fujita, Hiroyuki, Maruta, Atsuo, Naitoh, Akitaka, Nakamura, Satoshi, Ota, Yasuhiro, Nozue, Norio, Kihara, Minoru, Ishigatsubo, Yoshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Dalteparin - therapeutic use Drug Administration Schedule Gabexate - therapeutic use Guanidines - therapeutic use Humans Idarubicin - therapeutic use Kidney Neoplasms - complications Leukemia, Promyelocytic, Acute - complications Leukemia, Promyelocytic, Acute - drug therapy Male Nephritis, Interstitial - chemically induced Nephritis, Interstitial - pathology Prostatic Neoplasms - complications Thrombophilia - complications Tretinoin - administration & dosage Tretinoin - adverse effects
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Zusammenfassung:	We report the first case of granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid (ATRA) in a patient with acute promyelocytic leukemia (APL). Acute renal failure during treatment with ATRA has been previously reported as a part of an ATRA syndrome or a thrombotic complication of a hypercoagulable state. This case indicates an alternative mechanism of acute renal failure occurring during ATRA therapy.
ISSN:	0959-4973 1473-5741
DOI:	10.1097/00001813-200109000-00005