The Effect of Treatment of Obstructive Sleep Apnea on Glycemic Control in Type 2 Diabetes

There is uncertainty about the effects of treating obstructive sleep apnea on glycemic control in patients with type 2 diabetes. To determine whether treatment of obstructive sleep apnea in patients with type 2 diabetes improves glycemic control. In this trial, we randomized patients with type 2 dia...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2016-08, Vol.194 (4), p.486-492
Hauptverfasser: Shaw, Jonathan E, Punjabi, Naresh M, Naughton, Matthew T, Willes, Leslee, Bergenstal, Richard M, Cistulli, Peter A, Fulcher, Greg R, Richards, Glenn N, Zimmet, Paul Z
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Sprache:eng
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Zusammenfassung:There is uncertainty about the effects of treating obstructive sleep apnea on glycemic control in patients with type 2 diabetes. To determine whether treatment of obstructive sleep apnea in patients with type 2 diabetes improves glycemic control. In this trial, we randomized patients with type 2 diabetes and no previous diagnosis of obstructive sleep apnea, with a glycated hemoglobin level of 6.5-8.5%, and an oxygen desaturation index of 15 or more events per hour to positive airway pressure therapy or to usual care. A total of 416 patients met the entry criteria as determined by each site and were randomized. Of the 298 participants who met centrally adjudicated entry criteria, no differences between the study groups were seen for change in glycated hemoglobin. Furthermore, there were no between-group differences when analyses were restricted to those with poorer baseline glycemic control, those with more severe sleep apnea, or those who were adherent to therapy. A greater fall in diastolic blood pressure occurred in the positive airway pressure group than in the usual care group (-3.5 mm Hg vs. -1.5 mm Hg; P = 0.07). This difference was significant in those who were adherent to positive airway pressure therapy (-4.4 mm Hg vs. -1.6 mm Hg; P = 0.02). There was a significant reduction in sleepiness in the positive airway pressure therapy group (P 
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201511-2260OC