Red blood cell sodium transport in patients with cirrhosis

Red blood cell sodium transport in patients with cirrhosis

Summary Patients with advanced cirrhosis have abnormal sodium homoeostasis. The study was undertaken to quantify the sodium transport across the plasma membrane of red blood cells (RBC) in patients with cirrhosis. RBC efflux and influx of sodium were studied in vitro with tracer 22Na+ according to l...

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Veröffentlicht in:Clinical physiology and functional imaging 2016-09, Vol.36 (5), p.359-367
Hauptverfasser: Henriksen, Ulrik Lütken, Kiszka-Kanowitz, Marianne, Bendtsen, Flemming, Henriksen, Jens H.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Biological Transport
Case-Control Studies
Enzyme Inhibitors - pharmacology
Erythrocytes - drug effects
Erythrocytes - metabolism
Female
Furosemide - pharmacology
homoeostatic sodium dysregulation
Humans
hyponatremia
Kinetics
Liver Cirrhosis - blood
Liver Cirrhosis - diagnosis
Male
Middle Aged
Ouabain - pharmacology
Sodium - blood
Sodium Potassium Chloride Symporter Inhibitors - pharmacology
sodium retention
sodium-potassium ATPase
Sodium-Potassium-Chloride Symporters - blood
Sodium-Potassium-Chloride Symporters - drug effects
Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
Sodium-Potassium-Exchanging ATPase - blood
tracer kinetics
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Zusammenfassung:Summary Patients with advanced cirrhosis have abnormal sodium homoeostasis. The study was undertaken to quantify the sodium transport across the plasma membrane of red blood cells (RBC) in patients with cirrhosis. RBC efflux and influx of sodium were studied in vitro with tracer 22Na+ according to linear kinetics in 24 patients with cirrhosis and 14 healthy controls. The sodium efflux was modified by ouabain (O), furosemide (F) and a combination of O and F (O + F). RBC sodium was significantly decreased (4·6 versus control 6·3 mmol l−1, P
ISSN:1475-0961
1475-097X
DOI:10.1111/cpf.12238