Novel synthetic chalcones induces apoptosis in human glioblastoma cells

Glioblastoma multiforme is the main and most frequent tumor in adults' central nervous system. With a survival average of 5% two years after diagnosis, this type of cancer is a main health problem. Substances like the chalcones have been tested in order to develop new treatments. Here, we studied the effects of three synthetic chalcones (A23, C31 and J11) on A172 and surgery obtained-glioma cells. All chalcones showed a decrease in cell viability, mainly C31. An increase in apoptosis levels with no further increase of necrosis was observed. This augmentation may be linked to the high oxidative effect found, caused by the increased presence of reactive oxygen species and nitric oxide production. Cell cycle distribution showed an arrest at G0/G1 and S phases, suggesting that C31 interferes in cell cycle control. Our results shall aid in directing future research with this substance and its antitumor effect. [Display omitted] •Synthetic chalcones were tested for viability and apoptosis/necrosis in glioma cells.•C31 lowered cell viability and increased apoptosis in a necrosis-independent manner.•C31 was further studied and revealed that it influences the cell cycle.•C31 also augments intracellular reactive oxygen species and nitric oxide levels.