S19Imaging Derived Regional Lung Function Using Hyperpolarised Xenon Mri (xe-mri) And Quantitative Computed Tomography (qct) In Chronic Obstructive Pulmonary Disease (copd)

Introduction and objectivesTo derive quantitative regional imaging lung function parameters using hyperpolarised xenon MRI (Xe-MRI) and computed tomography (QCT), and compare these to pulmonary function tests (PFTs) in subjects with chronic pulmonary obstructive disease (COPD).MethodsTwenty patients with COPD (stage II - IV GOLD criteria classification) underwent Xe-MRI at 1.5T, QCT, and PFTs.Whole lung and lobar percentage ventilated volumes were obtained using automated segmentation of multi-slice Xe-MRI ventilation images acquired at a breath hold of FRC + 1L using in-house software. Average whole lung apparent diffusion coefficients (ADCs) were calculated from multi-slice Xe-MRI diffusion-weighted images (b=20.855 sec/cm2). Percentage predicted PFT results were established for each participant.Whole lung and lobar QCT-derived metrics for emphysema and bronchial wall thickness were calculated from percentage of lung tissue with density of