Modeling of Magnetite Nanoparticles Behavior under Conditions of Microcirculation and Analysis of In Vivo Toxicity

The behavior of magnetite nanoparticles was studied in the cell chip microcapillaries. No aggregation of magnetite nanoparticles under conditions of long-term circulation was noted. Biodistribution and toxicity of magnetite nanoparticles (14 nm) and aminated magnetite after their intragastric admini...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2016-05, Vol.161 (1), p.116-119
Hauptverfasser:	Sakharov, D. A., Rudakovskaya, P. G., Maltseva, D. V., Trushkin, E. V., Tonevitskaya, S. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Animals, Outbred Strains Biomedical and Life Sciences Biomedicine Biotechnologies Cell Biology Drug Evaluation, Preclinical Drug Stability Internal Medicine Laboratory Medicine Liver - drug effects Liver - metabolism Liver - pathology Magnetite Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - toxicity Male Mass spectrometry Mice Microcirculation Microfluidic Analytical Techniques Models, Biological Nanoparticles Pathology Physiological aspects Solutions Tissue Distribution Toxicity
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Beschreibung
Zusammenfassung:	The behavior of magnetite nanoparticles was studied in the cell chip microcapillaries. No aggregation of magnetite nanoparticles under conditions of long-term circulation was noted. Biodistribution and toxicity of magnetite nanoparticles (14 nm) and aminated magnetite after their intragastric administration to mice were studied in vivo . According to mass spectrometry and microscopy data, accumulation of nanoparticles occurred mainly in the liver cells.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-016-3359-5