Psychopharmacological Effects of Alkaloid Z77 under Conditions of Posthypoxic Encephalopathy and Mechanisms of Their Development

Psychopharmacological effects of atisine-type diterpene alkaloid Z77 were studied under conditions of experimental posthypoxic encephalopathy. The preparation had a pronounced cerebroprotective effect consisting in normalization of orientation and exploratory behavior and conditioned activity in exp...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2016-05, Vol.161 (1), p.45-49
Hauptverfasser:	Zyuz’kov, G. N., Losev, E. A., Chaikovskii, A. V., Suslov, N. I., Zhdanov, V. V., Udut, E. V., Miroshnichenko, L. A., Simanina, E. V., Polyakova, T. Yu, Povet’eva, T. N., Nesterova, Yu. V., Stavrova, L. A., Udut, V. V., Minakova, M. Yu, Dygai, A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Alkaloids - pharmacology Alkaloids - therapeutic use Animal behavior Animals Biomedical and Life Sciences Biomedicine Brain - drug effects Brain Diseases - drug therapy Cell Biology Encephalopathy Exploratory Behavior - drug effects Internal Medicine Laboratory Medicine Male Mice Neural Stem Cells - drug effects Neurons Pathology Regenerative Medicine Stem cells
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Zusammenfassung:	Psychopharmacological effects of atisine-type diterpene alkaloid Z77 were studied under conditions of experimental posthypoxic encephalopathy. The preparation had a pronounced cerebroprotective effect consisting in normalization of orientation and exploratory behavior and conditioned activity in experimental animals. These changes were accompanied by significant increase in the number of neural stem cells in the paraventricular region of the brain and markedly enhanced production of neurotrophic growth factors by neural tissue microenvironment cells.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-016-3341-2