Comparison of Clinical Features in Blacks Versus Whites With Hypertrophic Cardiomyopathy

To date, there has not been a large systematic examination of the hypertrophic cardiomyopathy (HC) phenotype in blacks versus whites. In this study, we investigate differences in presentation of HC between blacks and whites. We included 441 consecutive patients with HC seen at the Johns Hopkins HC c...

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Veröffentlicht in:	The American journal of cardiology 2016-06, Vol.117 (11), p.1815-1820
Hauptverfasser:	Sorensen, Lars L., MD, PhD, Pinheiro, Aurelio, MD, PhD, Dimaano, Veronica Lea, MD, Pozios, Iraklis, MD, Nowbar, Alexandra, MBBS, BSc, Liu, Hongyun, MD, Luo, Hong-Chang, MD, Lin, Xiaoping, MD, Olsen, Niels T., MD, PhD, Hansen, Thomas F., MD, Sogaard, Peter, MD, DMSc, Abraham, Maria R., MD, Abraham, Theodore P., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Cardiac arrhythmia Cardiology Cardiomyopathy Cardiomyopathy, Hypertrophic - diagnosis Cardiomyopathy, Hypertrophic - ethnology Cardiomyopathy, Hypertrophic - physiopathology Cardiovascular Cross-Sectional Studies Echocardiography Electrocardiography European Continental Ancestry Group Female Follow-Up Studies Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Hypertension Male Maryland - epidemiology Middle Aged Morbidity - trends Phenotype Prognosis Prospective Studies Registries Time Factors Ultrasonic imaging
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Beschreibung
Zusammenfassung:	To date, there has not been a large systematic examination of the hypertrophic cardiomyopathy (HC) phenotype in blacks versus whites. In this study, we investigate differences in presentation of HC between blacks and whites. We included 441 consecutive patients with HC seen at the Johns Hopkins HC clinic in the period from February 2005 to June 2012. We compared 76 blacks for clinical presentation, electrocardiogram, exercise capacity, left ventricular morphology, and hemodynamics by echocardiography to 365 whites. Black patients with HC more often presented with abnormal electrocardiogram (93% vs 80%, p = 0.009), driven by a significant difference in repolarization abnormalities (79% vs 56%, p
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2016.03.017