Ligustrazine improves blood circulation by suppressing Platelet activation in a rat model of allergic asthma

Highlights • Ligustrazine suppressed bronchial hyper-responsiveness to methacholine. • Ligustrazine suppressed lung inflammation in asthmatic rats. • Ligustrazine exhibited potent immuno-modulatory and anti-inflammatory effects. • Ligustrazine improves blood circulation and ameliorated platelet acti...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2016-07, Vol.45, p.334-339
Hauptverfasser:	Wang, Yajuan, Zhu, Huizhi, Tong, Jiabing, Li, Zegeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - therapeutic use Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Asthma Asthma - blood Asthma - drug therapy Asthma - immunology Asthma - physiopathology Blood Circulation - drug effects Blood Platelets - drug effects Cell Adhesion - drug effects Chuan-xiong Cytokines - biosynthesis Disease Models, Animal Emergency Human Umbilical Vein Endothelial Cells Immuno-modulatory Inflammation Ligusticum Ligustrazine Male Platelet Activation - drug effects Pneumonia - immunology Pneumonia - prevention & control Pyrazines - administration & dosage Pyrazines - therapeutic use Rats, Sprague-Dawley Traditional chinese medicine
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Beschreibung
Zusammenfassung:	Highlights • Ligustrazine suppressed bronchial hyper-responsiveness to methacholine. • Ligustrazine suppressed lung inflammation in asthmatic rats. • Ligustrazine exhibited potent immuno-modulatory and anti-inflammatory effects. • Ligustrazine improves blood circulation and ameliorated platelet activation. • Ligustrazine is a potent agent for the treatment of allergic asthma
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2016.06.016