Neonatal vitamin D status is not associated with later risk of type 1 diabetes: results from two large Danish population-based studies

Aims/hypothesis The aim of this work was to assess whether neonatal levels of 25-hydroxyvitamin D (25(OH)D) are associated with risk of developing type 1 diabetes before the age of 18 years. Methods Two large-scale studies with different designs—a case-cohort and a case–control—were conducted using...

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Veröffentlicht in:Diabetologia 2016-09, Vol.59 (9), p.1871-1881
Hauptverfasser: Jacobsen, Ramune, Thorsen, Steffen U., Cohen, Arieh S., Lundqvist, Marika, Frederiksen, Peder, Pipper, Christian B., Pociot, Flemming, Thygesen, Lau C., Ascherio, Alberto, Svensson, Jannet, Heitmann, Berit L.
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Sprache:eng
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Zusammenfassung:Aims/hypothesis The aim of this work was to assess whether neonatal levels of 25-hydroxyvitamin D (25(OH)D) are associated with risk of developing type 1 diabetes before the age of 18 years. Methods Two large-scale studies with different designs—a case-cohort and a case–control—were conducted using Danish national register data and biobank material. Weighted Cox regression and conditional logistic regression were used to calculate HRs and ORs, respectively. The concentration of 25(OH)D was assessed from neonatal dried blood spots using highly sensitive liquid chromatography–tandem mass spectrometry. Quintiles of 25(OH)D 3 were used in the main analyses. Results The case-cohort study included 912 type 1 diabetes cases and 2866 individuals without type 1 diabetes born in Denmark between 1981 and 2002 and followed up until the end of 2012. The case–control study included 527 matched case–control pairs born between 1981 and 1999 and followed up until May 2004. Both studies found no association between 25(OH)D 3 levels and later risk of developing type 1 diabetes. The neonatal total 25(OH)D levels in the studies were low: 46% (case-cohort study) and 51% (case–control study) of individuals had 25(OH)D levels
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-016-4002-8