NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated macrophages and cancer cells

Highlights • NCAM expression in PBMo-derived macrophages is significantly up-regulated by TECM. • Polarization of TAM promotes migration and survival through PI3K-Akt and FGFR1. • NCAM is involved in TAM migration/survival through PI3K-Akt and FGFR1 signaling. • FGF-2 promotes TAM and ESCC cell migr...

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Veröffentlicht in:	Cancer letters 2016-09, Vol.380 (1), p.47-58
Hauptverfasser:	Takase, Nobuhisa, Koma, Yu-ichiro, Urakawa, Naoki, Nishio, Mari, Arai, Noriaki, Akiyama, Hiroaki, Shigeoka, Manabu, Kakeji, Yoshihiro, Yokozaki, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomedical research Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell adhesion & migration Cell Line, Tumor Cell Movement Cell Survival Culture Media, Conditioned - metabolism Esophageal cancer Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma Female FGF-2 FGFR1 Fibroblast Growth Factor 2 - metabolism Genotype & phenotype Hematology, Oncology and Palliative Medicine Humans Macrophage Macrophages - metabolism Macrophages - pathology Male Medical prognosis Middle Aged NCAM Neural Cell Adhesion Molecules - genetics Neural Cell Adhesion Molecules - metabolism Paracrine Communication Phenotype Phosphatidylinositol 3-Kinase - metabolism Proto-Oncogene Proteins c-akt - metabolism Receptor, Fibroblast Growth Factor, Type 1 - metabolism RNA Interference Signal Transduction Stromal Cells - metabolism Stromal Cells - pathology Transfection Tumor Microenvironment
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Beschreibung
Zusammenfassung:	Highlights • NCAM expression in PBMo-derived macrophages is significantly up-regulated by TECM. • Polarization of TAM promotes migration and survival through PI3K-Akt and FGFR1. • NCAM is involved in TAM migration/survival through PI3K-Akt and FGFR1 signaling. • FGF-2 promotes TAM and ESCC cell migration/survival through FGF-2/FGFR1. • Up-regulated FGF-2 in stroma is associated with more aggressive ESCC phenotypes.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.06.009