Antibody persistence after serogroup C meningococcal conjugate vaccine in children with sickle cell disease
Abstract Background A decline of protective antibody titers after MCC vaccine has been demonstrated in healthy children, this may be an issue of concern for risk groups. The aim of this study was to evaluate the persistence of bactericidal antibodies after MCC vaccine in sickle cell disease (SCD) pa...
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Veröffentlicht in: | Vaccine 2016-08, Vol.34 (36), p.4327-4334 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Abstract Background A decline of protective antibody titers after MCC vaccine has been demonstrated in healthy children, this may be an issue of concern for risk groups. The aim of this study was to evaluate the persistence of bactericidal antibodies after MCC vaccine in sickle cell disease (SCD) patients. The type of vaccine used and booster response were also analyzed. Methods SCD patients ( n = 141) previously immunized with MCC vaccines had blood drawn 2–8 years after the last priming dose. They were distributed according to age at primary immunization into groups: |
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ISSN: | 0264-410X 1873-2518 |
DOI: | 10.1016/j.vaccine.2016.06.072 |