Search for New Bioactive Marine Natural Products and Application to Drug Development

Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) and microorganisms (fungi, bacteria, di...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2016/08/01, Vol.64(8), pp.1079-1083
1. Verfasser:	Kobayashi, Jun’ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Shells - chemistry Animals Bacteria - chemistry bioactive natural product Biological Products - chemistry dinoflagellate Dinoflagellida - chemistry Drug Discovery Fungi - chemistry marine bacteria marine sponge marine-derived fungi Porifera tunicate Urochordata
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Beschreibung
Zusammenfassung:	Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) and microorganisms (fungi, bacteria, dinoflagellates, etc.). Some of them are used as bioprobes useful for basic studies of life sciences, while others are expected to be candidates of drug leads.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c16-00281