Effects of Combined Exposure to Formaldehyde and Benzene on Immune Cells in the Blood and Spleen in Balb/c Mice

Highlights • Formaldehyde (FA) has certain synergistic effects on benzene-induced cytotoxicity in peripheral blood. • Benzene (BZ) and FA + BZ exposure can lead to the reduction in the number of some immune cells in peripheral blood. • FA + BZ combined exposure can lead to the decreased body weight...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2016-07, Vol.45, p.265-273
Hauptverfasser:	Wen, Huaxiao, Yuan, Langyue, Wei, Chenxi, Zhao, Yun, Qian, Yan, Ma, Ping, Ding, Shumao, Yang, Xu, Wang, Xianliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants - toxicity Animals Apoptosis - drug effects Apoptosis - immunology Benzene Benzene - toxicity Blood Cell Proliferation - drug effects Cell Survival - drug effects Cell Survival - immunology Combined exposure Drug Synergism Emergency Formaldehyde Formaldehyde - toxicity Glutathione - metabolism Immunotoxicity Inhalation Exposure Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Male Mice, Inbred BALB C Oxidative damage Oxidative Stress - drug effects Oxidative Stress - immunology Reactive Oxygen Species - metabolism Spleen Spleen - cytology Spleen - drug effects Spleen - immunology
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Zusammenfassung:	Highlights • Formaldehyde (FA) has certain synergistic effects on benzene-induced cytotoxicity in peripheral blood. • Benzene (BZ) and FA + BZ exposure can lead to the reduction in the number of some immune cells in peripheral blood. • FA + BZ combined exposure can lead to the decreased body weight and serum antibody level.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2016.05.007