Relationship between CYP2B66 and cold pressor pain sensitivity in opioid dependent patients on methadone maintenance therapy (MMT)

Relationship between CYP2B66 and cold pressor pain sensitivity in opioid dependent patients on methadone maintenance therapy (MMT)

Highlights • CYP2B6 polymorphisms contribute to variations in methadone pharmacokinetics. • CYP2B6*6 carriers had shorter pain threshold than CYP2B6*6 non-carriers. • Pain tolerance was also shorter in the CYP2B6*6 carriers. • CYP2B6*6 influences pain sensitivity among patients on methadone maintena...

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Veröffentlicht in:Drug and alcohol dependence 2016-08, Vol.165, p.143-150
Hauptverfasser: Zahari, Zalina, Lee, Chee Siong, Ibrahim, Muslih Abdulkarim, Musa, Nurfadhlina, Mohd Yasin, Mohd Azhar, Lee, Yeong Yeh, Tan, Soo Choon, Mohamad, Nasir, Ismail, Rusli
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Alleles
Analgesics, Opioid - therapeutic use
Cold pressor test (CPT)
CYP2B6
CYP2B66
Cytochrome P-450 CYP2B6 - genetics
Genotype
Heterozygote
Humans
Male
Male patients
Methadone - blood
Methadone - pharmacokinetics
Methadone - therapeutic use
Methadone maintenance therapy (MMT)
Opiate Substitution Treatment
Opioid dependence
Opioid-Related Disorders - drug therapy
Pain - drug therapy
Pain - genetics
Pain sensitivity
Pain Threshold - drug effects
Polymorphism, Genetic
Psychiatry
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Beschreibung
Zusammenfassung:Highlights • CYP2B6 polymorphisms contribute to variations in methadone pharmacokinetics. • CYP2B6*6 carriers had shorter pain threshold than CYP2B6*6 non-carriers. • Pain tolerance was also shorter in the CYP2B6*6 carriers. • CYP2B6*6 influences pain sensitivity among patients on methadone maintenance therapy.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2016.05.028