Whom to blame for metastasis, the epithelial–mesenchymal transition or the tumor microenvironment?

Whom to blame for metastasis, the epithelial–mesenchymal transition or the tumor microenvironment?

Highlights • The latent embryonic program EMT is essential for the metastatic activity of carcinoma cells. • Tumor cells together with the tumor microenvironment (TME) form organ-like structures. • Changes in the TME induces EMT program in epithelial carcinoma cells. • Carcinoma cells that have unde...

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Veröffentlicht in:Cancer letters 2016-09, Vol.380 (1), p.359-368
Hauptverfasser: Pietilä, M, Ivaska, J, Mani, S.A
Format: Artikel
Sprache:eng
Schlagworte:
Adipocytes
Animals
Breast cancer
Cancer stem cells
Cell Communication
Cell Movement
Conflicts of interest
Energy Metabolism
Epigenetics
Epithelial-Mesenchymal Transition
Epithelial-to-mesenchymal transition
Extracellular Matrix - metabolism
Extracellular Matrix - pathology
Hematology, Oncology and Palliative Medicine
Humans
Hypoxia
Immune modulation
Immune system
Mesenchymal Stromal Cells - metabolism
Mesenchymal Stromal Cells - pathology
Metabolism
Metabolites
Metastasis
Neoplasm Metastasis
Neoplasms - immunology
Neoplasms - metabolism
Neoplasms - pathology
Neoplastic Stem Cells - immunology
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Phenotype
Signal Transduction
Stem cells
Transcription factors
Tumor Microenvironment
Tumor stroma
Tumors
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Beschreibung
Zusammenfassung:Highlights • The latent embryonic program EMT is essential for the metastatic activity of carcinoma cells. • Tumor cells together with the tumor microenvironment (TME) form organ-like structures. • Changes in the TME induces EMT program in epithelial carcinoma cells. • Carcinoma cells that have undergone an EMT influences TME. • The bidirectional cross talk between mesenchymal-looking carcinoma cells and the TME impact every stage of the metastatic cascade.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.12.033