Adipocytes contribute to the growth and progression of multiple myeloma: Unraveling obesity related differences in adipocyte signaling

Highlights • BMI negatively correlates with adipose-derived stem cell viability. • Adipocytes increase p-STAT3/STAT3 signaling in multiple myeloma cells. • Adipocytes increase multiple myeloma cell viability in a BMI-dependent manner. • Adipocytes from obese patients increase adhesion of multiple my...

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Veröffentlicht in:	Cancer letters 2016-09, Vol.380 (1), p.114-121
Hauptverfasser:	Bullwinkle, Erica M, Parker, Melissa D, Bonan, Nicole F, Falkenberg, Lauren G, Davison, Steven P, DeCicco-Skinner, Kathleen L
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Adhesion Adipocyte Adipocytes Adipocytes - metabolism Adipocytes - pathology Adipose-derived stem cells Angiogenesis Bone marrow Cancer Cell Adhesion Cell Line, Tumor Cell Proliferation Coculture Techniques Culture Media, Conditioned - metabolism Cytochromes c - metabolism Cytokines Disease Progression Fatty Acid Synthase, Type I - metabolism Hematology, Oncology and Palliative Medicine Human Umbilical Vein Endothelial Cells - metabolism Humans Insulin Interleukin-6 - metabolism Leptin - metabolism Matrix Metalloproteinase 2 - metabolism Medical prognosis Metastasis Multiple myeloma Multiple Myeloma - complications Multiple Myeloma - metabolism Multiple Myeloma - pathology Neovascularization, Physiologic Obesity Obesity - complications Obesity - metabolism Obesity - pathology Paracrine Communication Phosphorylation PPAR gamma - metabolism Proteins Signal Transduction STAT3 Transcription Factor - metabolism Tumor Microenvironment
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Zusammenfassung:	Highlights • BMI negatively correlates with adipose-derived stem cell viability. • Adipocytes increase p-STAT3/STAT3 signaling in multiple myeloma cells. • Adipocytes increase multiple myeloma cell viability in a BMI-dependent manner. • Adipocytes from obese patients increase adhesion of multiple myeloma cells. • Adipocytes increase endothelial cell tube formation in a BMI-dependent manner.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.06.010