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Editorial Comment: Manesh R. Patel, p. 1885 Cardiometabolic Risk AMG 145 Effects on LDL-C, Safety, and Tolerability 1888 Clapton S. Dias, Adam J. Shaywitz, Scott M. Wasserman, Brian P. Smith, Bing Gao, Dina S. Stolman, Caroline P. Crispino, Karen V. Smirnakis, Maurice G. Emery, Alexander Colbert, John P. Gibbs, Marc W. Retter, Blaire Cooke, Stephen T. Uy, Mark Matson, Evan A. Stein Proprotein convertase subtilisin/kexin type 9 (PCSK9) down-regulates surface expression of the low-density lipoprotein receptor (LDL-R), increasing serum low-density lipoprotein cholesterol (LDL-C). Heart Failure Correlations Between Exercise Volume and Clinical Outcomes in Patients With Heart Failure 1899 Steven J. Keteyian, Eric S. Leifer, Nancy Houston-Miller, William E. Kraus, Clinton A. Brawner, Christopher M. O'Connor, David J. Whellan, Lawton S. Cooper, Jerome L. Fleg, Dalane W. Kitzman, Alain Cohen-Solal, James A. Blumenthal, David S. Rendall, Ileana L. Pinã, for the HF-ACTION Investigators The HF-ACTION trial showed that among patients with heart failure (HF), regular exercise reduces the risk for all-cause mortality or hospitalization.