Genotypic resistance test in proviral DNA can identify resistance mutations never detected in historical genotypic test in patients with low level or undetectable HIV-RNA

Highlights • PBMC GRT can be useful when previous plasma resistance information is not available. • PBMC GRT is a valid tool in case of low/undetectable HIV-RNA. • PBMC resistance is related to drugs with a low genetic barrier. • PBMC GRT might detect mutations not present in plasma compartment...

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Veröffentlicht in:	Journal of clinical virology 2016-09, Vol.82, p.94-100
Hauptverfasser:	Zaccarelli, Mauro, Mercedes Santoro, Maria, Armenia, Daniele, Borghi, Vanni, Gennari, William, Gori, Caterina, Forbici, Federica, Bertoli, Ada, Fabeni, Lavinia, Giannetti, Alberto, Cicalini, Stefania, Bellagamba, Rita, Andreoni, Massimo, Mastroianni, Claudio Maria, Mussini, Cristina, Ceccherini-Silberstein, Francesca, Perno, Carlo Federico, Antinori, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology DNA, Viral - genetics Drug Resistance, Viral Female Genotyping Techniques - methods HIV Infections - virology HIV reservoir HIV-1 - drug effects HIV-1 - genetics HIV-DNA Humans Infectious Disease Leukocytes, Mononuclear - virology Male Microbial Sensitivity Tests - methods Middle Aged Mutation PBMC resistance Proviral DNA Proviruses - genetics Resistance genotyping Resistance mutations Retrospective Studies RNA, Viral - genetics Sensitivity and Specificity
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Beschreibung
Zusammenfassung:	Highlights • PBMC GRT can be useful when previous plasma resistance information is not available. • PBMC GRT is a valid tool in case of low/undetectable HIV-RNA. • PBMC resistance is related to drugs with a low genetic barrier. • PBMC GRT might detect mutations not present in plasma compartment
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2016.07.007