Occurrence, risk factors and outcome of adenovirus infection in adult recipients of allogeneic hematopoietic stem cell transplantation

Occurrence, risk factors and outcome of adenovirus infection in adult recipients of allogeneic hematopoietic stem cell transplantation

Highlights • ADV infection: moderate occurrence in adult hematopoietic stem cell transplantation. • Risk factors ADV infection: lower age, alternative donor grafts, acute GvHD ≥ °II. • Few ADV infection in post-grafting cyclophosphamide haploidentical transplantation. • Disseminated ADV disease rema...

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Veröffentlicht in:Journal of clinical virology 2016-09, Vol.82, p.33-40
Hauptverfasser: Hubmann, Max, Fritsch, Susanne, Zoellner, Anna-Katharina, Prevalsek, Dusan, Engel, Nicole, Bücklein, Veit, Mumm, Friederike, Schulz, Christoph, Stemmler, Hans Joachim, Jäger, Gundula, Ledderose, Georg, Kolb, Hans Jochem, Hausmann, Andreas, Hiddemann, Wolfgang, Moosmann, Andreas, Tischer, Johanna
Format: Artikel
Sprache:eng
Schlagworte:
Adenoviridae Infections - epidemiology
Adenoviridae Infections - mortality
Adenovirus
Adolescent
Adult
Aged
Allergy and Immunology
Allogeneic hematopoietic stem cell transplantation
Alternative donor transplantation
Antiviral Agents - therapeutic use
Disseminated disease
Female
Hematologic Diseases - complications
Hematologic Diseases - therapy
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Immunocompromised Host
Infectious Disease
Male
Middle Aged
Retrospective Studies
Risk Factors
Survival Analysis
Transplantation, Homologous - adverse effects
Treatment Outcome
Young Adult
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Zusammenfassung:Highlights • ADV infection: moderate occurrence in adult hematopoietic stem cell transplantation. • Risk factors ADV infection: lower age, alternative donor grafts, acute GvHD ≥ °II. • Few ADV infection in post-grafting cyclophosphamide haploidentical transplantation. • Disseminated ADV disease remains a therapeutic challenge
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2016.07.002