Prevalence of diabetes mellitus and prediabetes in the adult Romanian population: PREDATORR study

Background The PREDATORR (PREvalence of DiAbeTes mellitus, prediabetes, overweight, Obesity, dyslipidemia, hyperuricemia and chronic kidney disease in Romania) study is the first national study analyzing the prevalence of diabetes mellitus (DM) and prediabetes, and their association with cardiometabolic, sociodemographic, and lifestyle risk factors in the Romanian population aged 20–79 years. Methods This was an epidemiological study with a stratified, cross‐sectional, cluster random sampling design. Sociodemographic, lifestyle, and anamnestic data were collected through self‐ and interviewer‐administered questionnaires, and biochemical assays and oral glucose tolerance tests were performed. Results In all, 2728 participants from 101 clinics of general practitioners were randomly selected, with a probability proportional to population size according to the 2002 Romanian Census. The participation rate was 99.6%. Impaired glucose regulation (prediabetes, known and unknown DM) was found in 28.1% of the study population. The overall age‐ and sex‐adjusted prevalence of DM was 11.6% (95%CI 9.6%–13.6%), of which 2.4% (95%CI 1.7%–3.1%) had unknown DM. The prevalence of DM increased with age and was higher in men than in women. The age‐ and sex‐adjusted prevalence of prediabetes was 16.5% (95%CI 14.8%–18.2%), with the highest percentage in the 60–79 year age group and in women. Obesity, abdominal obesity, dyslipidemia, low education level, and a family history of diabetes were associated with glucose metabolism disorders. Conclusions The PREDATORR study shows a high prevalence of impaired glucose regulation in the adult Romanian population, providing data on the prevalence of DM and prediabetes and their association with several risk factors. 摘要 背景 罗马尼亚糖尿病、糖尿病前期、超重、肥胖、血脂异常、高尿酸血症以及慢性肾脏病变的患病率(PREvalence of DiAbeTes mellitus, prediabetes, overweight, Obesity, dyslipidemia, hyperuricemia and chronic kidney disease in Romania,PREDATORR)研究是一项全国性的研究,它首次在罗马尼亚20‐79岁的人群中分析了糖尿病、糖尿病前期的患病率以及它们与心脏代谢、社会人口学数据、生活方式危险因素之间的关系。 方法 这是一项分层、横断面、整群随机抽样设计的流行病学研究。通过自我或者面谈填写的问卷来搜集社会人口学、生活方式以及回忆的数据,并且还进行了生化分析与口服葡萄糖耐量试验。 结果 总共随机选择了2728名参与者,他们分别来自101个全科医生诊所,根据2002年罗马尼亚人口普查数据这是一个人口规模比例相称的样本。参与率为99.6%。发现在这个研究人群中糖调节受损(糖尿病前期、已知的以及既往未知的糖尿病)的比例为28.1%。经过年龄与性别校正后的全体糖尿病患病率为11.6%(95% CI为9.6%‐13.6%),其中2.4%(95% CI为1.7%‐3.1%)为既往未知的糖尿病。糖尿病患病率随着年龄增加而不断增加,男性与女性相比患病率更高。经过年龄与性别校正后的糖尿病前期患病率为16.5%(95% CI为14.8%‐18.2%),其中女性60‐79岁年龄组的比例最高。肥胖、腹型肥胖、血脂异常、较低的教育水平以及糖尿病家族史都与糖代谢紊乱有关。 结论 PREDATORR研究结果表明在罗马尼亚成年人群中糖调节受损的患病率非常高