Toward a structural understanding of co-translational protein translocation

Toward a structural understanding of co-translational protein translocation

Highlights • Advances in cryo-electron microscopy allow analysis of low abundance native complexes. • Near-atomic resolution structures of intermediates in co-translational translocation. • Cryo-electron tomography reveals translocon structure in its native lipid environment.

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Bibliographische Detailangaben
Veröffentlicht in:Current opinion in cell biology 2016-08, Vol.41, p.91-99
Hauptverfasser: Voorhees, Rebecca M, Hegde, Ramanujan S
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Internal Medicine
Intracellular Membranes - metabolism
Protein Transport
Proteins - chemistry
Proteins - metabolism
Secretory Pathway
Signal Recognition Particle - chemistry
Signal Recognition Particle - metabolism
Translocation, Genetic
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Zusammenfassung:Highlights • Advances in cryo-electron microscopy allow analysis of low abundance native complexes. • Near-atomic resolution structures of intermediates in co-translational translocation. • Cryo-electron tomography reveals translocon structure in its native lipid environment.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2016.04.009