Safety and effectiveness of the new P2Y12r inhibitor agents vs clopidogrel in ACS patients according to the geographic area: East Asia vs Europe

In the setting of the Acute Coronary Syndrome (ACS), differences in response to prasugrel and ticagrelor between East Asian and European patients have not been investigated yet. This is a sub-analysis of the “BleeMACS registry”. Patients admitted for ACS and underwent PCI from between 2012 and 2014...

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Veröffentlicht in:	International journal of cardiology 2016-10, Vol.220, p.488-495
Hauptverfasser:	Giordana, Francesca, Montefusco, Antonio, D'Ascenzo, Fabrizio, Moretti, Claudio, Scarano, Silvia, Abu-Assi, Emad, Raposeiras-Roubín, Sergio, Henriques, Jose Paulo Simao, Saucedo, Jorge, González-Juanatey, José Ramón, Wilton, Stephen B., Kikkert, Wouter J., Nuñez-Gil, Iván, Ariza-Sole, Albert, Song, Xiantao, Alexopoulos, Dimitrios, Liebetrau, Christoph, Kawaji, Tetsuma, Huczek, Zenon, Nie, Shao-Ping, Fujii, Toshiharu, Correia, Luis, Kawashiri, Masa-aki, García-Acuña, José María, Southern, Danielle, Alfonso, Emilio, Terol, Belén, Garay, Alberto, Zhang, Dongfeng, Chen, Yalei, Xanthopoulou, Ioanna, Osman, Neriman, Möllmann, Helge, Shiomi, Hiroki, Kowara, Michal, Filipiak, Krzysztof, Wang, Xiao, Yan, Yan, Fan, Jing-Yao, Ikari, Yuji, Nakahayshi, Takuya, Sakata, Kenji, Yamagishi, Masakazu, Kalpak, Oliver, Kedev, Sasko, Gaita, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndrome Acute Coronary Syndrome - drug therapy Acute Coronary Syndrome - ethnology Aged Clopidogrel Ethnicity Europe - ethnology Far East - ethnology Female Follow-Up Studies Hemorrhage - chemically induced Hemorrhage - epidemiology Humans Internationality Male Middle Aged P2Y12 receptor Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - therapeutic use Platelet inhibitor Prasugrel Purinergic P2Y Receptor Antagonists - adverse effects Purinergic P2Y Receptor Antagonists - therapeutic use Registries Retrospective Studies Ticagrelor Ticlopidine - adverse effects Ticlopidine - analogs & derivatives Ticlopidine - therapeutic use Treatment Outcome
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Zusammenfassung:	In the setting of the Acute Coronary Syndrome (ACS), differences in response to prasugrel and ticagrelor between East Asian and European patients have not been investigated yet. This is a sub-analysis of the “BleeMACS registry”. Patients admitted for ACS and underwent PCI from between 2012 and 2014 were stratified first according to their provenance, Europe vs. East Asia (China and Japan), and then by country. The adjusted rate of 1-year serious bleeding -safety end-point- and 1-year death/re-infarction -effectiveness endpoint- of the new P2Y12r inhibitors were compared. Data of 10004 patients in Europe and 2332 patients in East Asia were collected. At baseline prior stroke (6% vs 9%, p
ISSN:	0167-5273 1874-1754
DOI:	10.1016/j.ijcard.2016.06.063