Human age estimation from blood using mRNA, DNA methylation, DNA rearrangement, and telomere length

Highlights • Estimating a person’s age from blood left at a crime scene provides crucial forensic information. • We studied the age effect of mRNA, DNA methylation, sjTREC, telomere length in blood. • Genome-wide marker search was followed by rigorous technical and biological validations. • Overall,...

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Veröffentlicht in:	Forensic science international : genetics 2016-09, Vol.24, p.33-43
Hauptverfasser:	Zubakov, Dmitry, Liu, Fan, Kokmeijer, Iris, Choi, Ying, van Meurs, Joyce B.J, van IJcken, Wilfred F.J, Uitterlinden, André G, Hofman, Albert, Broer, Linda, van Duijn, Cornelia M, Lewin, Jörn, Kayser, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aging - genetics Biomarkers - blood Blood biomarkers Blood Chemical Analysis CpG Islands - genetics DNA Methylation Forensic Gene expression Gene Expression Profiling Gene Rearrangement Human age estimation Humans Male Microarray Analysis Middle Aged mRNA Pathology Polymerase Chain Reaction RNA, Messenger - genetics sjTREC Telomere - genetics Telomere length Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Estimating a person’s age from blood left at a crime scene provides crucial forensic information. • We studied the age effect of mRNA, DNA methylation, sjTREC, telomere length in blood. • Genome-wide marker search was followed by rigorous technical and biological validations. • Overall, DNA methylation markers outperformed in age correlation all other biomarkers tested. • A model with 8 DNA methylation markers achieved high accuracy in estimating age from blood.
ISSN:	1872-4973 1878-0326
DOI:	10.1016/j.fsigen.2016.05.014