Gene expression in Kinetoplastids

Highlights • Kinetoplastids do not control transcription of individual protein-coding genes. • mRNAs are made from polycistronic precursors by trans splicing and polyadenylation. • Nuclear mRNA processing competes with precursor degradation. • RNA-binding proteins control mRNA processing, translatio...

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Veröffentlicht in:	Current opinion in microbiology 2016-08, Vol.32, p.46-51
1. Verfasser:	Clayton, CE
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Expression - genetics Gene Expression Regulation - genetics Leishmania - genetics Pathology Protein Biosynthesis - genetics RNA Processing, Post-Transcriptional - physiology RNA Stability - physiology RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - metabolism Signal Transduction - genetics Trypanosoma brucei brucei - genetics
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Beschreibung
Zusammenfassung:	Highlights • Kinetoplastids do not control transcription of individual protein-coding genes. • mRNAs are made from polycistronic precursors by trans splicing and polyadenylation. • Nuclear mRNA processing competes with precursor degradation. • RNA-binding proteins control mRNA processing, translation and decay. • Every mRNA can bind many different proteins, which may compete or cooperate.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2016.04.018