The impact of Toxoplasma gondii on the mammalian genome

Highlights • Correlating specific genomic modifications with particular infections is difficult. • T. gondii is a ubiquitous parasite but depends on infection of small mammals for transmission to cats. • Humans lack both recognition and effector proteins required by mice for resistance to T. gondii....

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Veröffentlicht in:	Current opinion in microbiology 2016-08, Vol.32, p.19-25
Hauptverfasser:	Müller, Urs B, Howard, Jonathan C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cats Genome - genetics Host-Pathogen Interactions - genetics Host-Pathogen Interactions - immunology Humans Hydro-Lyases - genetics Mice Pathology Toll-Like Receptors - genetics Toll-Like Receptors - immunology Toxoplasma - genetics Toxoplasma - immunology Toxoplasma - pathogenicity Toxoplasmosis - parasitology Toxoplasmosis - pathology Virulence - genetics
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Beschreibung
Zusammenfassung:	Highlights • Correlating specific genomic modifications with particular infections is difficult. • T. gondii is a ubiquitous parasite but depends on infection of small mammals for transmission to cats. • Humans lack both recognition and effector proteins required by mice for resistance to T. gondii. • Reciprocal polymorphism between T. gondii virulence and mouse resistance proteins suggests a co-evolving system.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2016.04.009