Amino acid biosynthetic routes as drug targets for pulmonary fungal pathogens: what is known and why do we need to know more?

Highlights • Many fungal amino acid biosynthetic pathways are conserved in microbes but absent from humans. • Several of the involved enzymes have now been found to be essential for fungal viability. • Therapeutic targets must always be tested in systemic disease, currently not commonplace. • Much m...

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Veröffentlicht in:	Current opinion in microbiology 2016-08, Vol.32, p.151-158
Hauptverfasser:	Amich, Jorge, Bignell, Elaine
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - biosynthesis Amino Acids - metabolism Animals Aspergillosis - microbiology Aspergillosis - pathology Aspergillus fumigatus - metabolism Aspergillus fumigatus - pathogenicity Cryptococcosis - microbiology Cryptococcosis - pathology Cryptococcus neoformans - metabolism Cryptococcus neoformans - pathogenicity Humans Lung - microbiology Lung - pathology Metabolic Networks and Pathways - physiology Pathology
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Zusammenfassung:	Highlights • Many fungal amino acid biosynthetic pathways are conserved in microbes but absent from humans. • Several of the involved enzymes have now been found to be essential for fungal viability. • Therapeutic targets must always be tested in systemic disease, currently not commonplace. • Much more work required in amino acid biosynthesis in particular in the dimorphic species.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2016.06.003