Ewing sarcoma: a chronicle of molecular pathogenesis

Sarcomas have traditionally been classified according to their chromosomal alterations regardless of whether they accompany simple or complex genetic changes. Ewing sarcoma, a classic small round cell bone tumor, is a well-known mesenchymal malignancy that results from simple sarcoma-specific geneti...

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Veröffentlicht in:	Human pathology 2016-09, Vol.55, p.91-100
Hauptverfasser:	Kim, Sang Kyum, MD, PhD, Park, Yong-Koo, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	12E7 Antigen - analysis Angiogenesis Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Bone Neoplasms - chemistry Bone Neoplasms - genetics Bone Neoplasms - pathology Cell division Chromosomal translocation Chromosome Aberrations Chromosomes Diagnosis, Differential Epigenesis, Genetic Epigenetics Ewing sarcoma Gene Expression Regulation, Neoplastic Genes Genetic Predisposition to Disease Humans Immunohistochemistry Leukemia Lymphoma Molecular Diagnostic Techniques Molecular pathogenesis Pathogenesis Pathology Phenotype Predictive Value of Tests Prognosis Protein expression Proteins Sarcoma, Ewing - chemistry Sarcoma, Ewing - genetics Sarcoma, Ewing - pathology Studies Transcription, Genetic Translocation, Genetic Tumorigenesis Tumors
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Zusammenfassung:	Sarcomas have traditionally been classified according to their chromosomal alterations regardless of whether they accompany simple or complex genetic changes. Ewing sarcoma, a classic small round cell bone tumor, is a well-known mesenchymal malignancy that results from simple sarcoma-specific genetic alterations. The genetic alterations are translocations between genes of the TET/FET family ( TLS/FUS, EWSR1, and TAF15 ) and genes of the ETS (E26 transformation-specific) family. In this review, we intend to summarize a chronicle of molecular findings of Ewing sarcoma including recent advances and explain resultant molecular pathogenesis.
ISSN:	0046-8177 1532-8392
DOI:	10.1016/j.humpath.2016.05.008