The relationship between seizures, interictal spikes and antiepileptic drugs

Highlights • Interictal EEG spikes demonstrate a considerable diurnal variation with a night-time peak and day-time trough. • Spike rate decreases with AED taper, increases after seizures and is higher for longer seizure-free periods. • Interictal EEG spikes may reflect a process that contributes to...

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Veröffentlicht in:	Clinical neurophysiology 2016-09, Vol.127 (9), p.3180-3186
Hauptverfasser:	Goncharova, Irina I, Alkawadri, Rafeed, Gaspard, Nicolas, Duckrow, Robert B, Spencer, Dennis D, Hirsch, Lawrence J, Spencer, Susan S, Zaveri, Hitten P
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Adolescent Adult Aged Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Antiepileptic drugs Child Cohort Studies Cross-Sectional Studies Drug Resistant Epilepsy - drug therapy Drug Resistant Epilepsy - physiopathology EEG Electroencephalography - drug effects Electroencephalography - methods Epilepsy Epilepsy monitoring Female Humans Interictal spikes Male Middle Aged Neurology Seizures Seizures - drug therapy Seizures - physiopathology Young Adult
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Zusammenfassung:	Highlights • Interictal EEG spikes demonstrate a considerable diurnal variation with a night-time peak and day-time trough. • Spike rate decreases with AED taper, increases after seizures and is higher for longer seizure-free periods. • Interictal EEG spikes may reflect a process that contributes to the prevention and not occurrence of seizures.
ISSN:	1388-2457 1872-8952
DOI:	10.1016/j.clinph.2016.05.014