Palladium-Catalyzed Nitration of Meyer–Schuster Intermediates with tBuONO as Nitrogen Source at Ambient Temperature

Palladium-Catalyzed Nitration of Meyer–Schuster Intermediates with tBuONO as Nitrogen Source at Ambient Temperature

A novel domino palladium-catalyzed nitration of Meyer–Schuster intermediates which were generated in situ from propargylic alcohols was developed, by the use of t-BuONO, leading to α-nitro enones in good to excellent yields at room temperature with a broad functional group tolerance.

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Veröffentlicht in:Organic letters 2016-08, Vol.18 (15), p.3702-3705
Hauptverfasser: Lin, Yuanguang, Kong, Weiguang, Song, Qiuling
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel domino palladium-catalyzed nitration of Meyer–Schuster intermediates which were generated in situ from propargylic alcohols was developed, by the use of t-BuONO, leading to α-nitro enones in good to excellent yields at room temperature with a broad functional group tolerance.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b01740