The B(C6F5)3‑Catalyzed Tandem Meinwald Rearrangement–Reductive Amination

A system of three coupled catalytic cycles enabling the one-pot transformation of epoxides to amines via Meinwald rearrangement, imine condensation, and imine reduction is described. This assisted tandem catalysis is catalyzed by B­(C6F5)3 resulting in the first tandem Meinwald rearrangement–reductive amination protocol. The reaction proceeds in nondried solvents and yields β-functionalized amines. In particular, β-diarylamines are obtained in high yields.