Depleted interstitial cells of Cajal and fibrosis in the pylorus: Novel features of gastroparesis

Background Depletion and ultrastructural changes of interstitial cells of Cajal (ICC) in the gastric body and antrum have been observed in gastroparesis. This research was performed to investigate the ICC population in the muscularis propria and fibrosis of the muscular layer of the pylorus in gastr...

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Veröffentlicht in:	Neurogastroenterology and motility 2016-07, Vol.28 (7), p.1048-1054
Hauptverfasser:	Moraveji, S., Bashashati, M., Elhanafi, S., Sunny, J., Sarosiek, I., Davis, B., Torabi, A., McCallum, R. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biopsy Case-Control Studies Colon Female Fibrosis Gastric Emptying - physiology gastroparesis Gastroparesis - pathology Gastroparesis - physiopathology Humans interstitial cells of Cajal Interstitial Cells of Cajal - pathology Interstitial Cells of Cajal - physiology Male Middle Aged Muscle, Smooth - pathology Muscle, Smooth - physiology pathology pylorus Pylorus - pathology Pylorus - physiology
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Zusammenfassung:	Background Depletion and ultrastructural changes of interstitial cells of Cajal (ICC) in the gastric body and antrum have been observed in gastroparesis. This research was performed to investigate the ICC population in the muscularis propria and fibrosis of the muscular layer of the pylorus in gastroparesis. Methods Full thickness pyloric and antral biopsies were obtained from 17 gastroparetic and 6 non‐gastroparetic controls. Biopsies were stained with C‐Kit for ICC and Trichrome for collagen fibrosis. Interstitial cells of Cajal depletion in the antrum was defined as mean ICC count
ISSN:	1350-1925 1365-2982
DOI:	10.1111/nmo.12806