Validation of the 2014 European Society of Cardiology Sudden Cardiac Death Risk Prediction Model in Hypertrophic Cardiomyopathy in a Reference Center in South America

Abstract Sudden cardiac death (SCD) is a common cause of death in hypertrophic cardiomyopathy (HC). Our aim was to conduct an external and independent validation in South America of the 2014 European Society of Cardiology (ESC) SCD risk prediction model to identify patients requiring an implantable cardioverter defibrillator (ICD). This study included 502 consecutive HC patients followed between March/1993 and December/2014. A combined endpoint of SCD or appropriate ICD therapy (AT) was assessed. For the quantitative estimation of individual 5-year SCD risk, we used the formula: 1–0.998exp(Prognostic index) . Our database also included the abnormal blood pressure response to exercise (ABPRE) as a risk marker. We analyzed the three categories of 5-year risk proposed by the ESC: low risk (LR)