Widespread alterations in the synaptic proteome of the adolescent cerebral cortex following prenatal immune activation in rats
Highlights • First study examining synaptic proteome changes due to prenatal immune activation. • Presynaptic molecular mechanisms are more affected than postsynaptic ones. • Several basic and synaptic cellular functions are influenced. • Camk2a is downregulated in the prefrontal cortex. • Our data...
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2016-08, Vol.56, p.289-309 |
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| creator | Györffy, Balázs A Gulyássy, Péter Gellén, Barbara Völgyi, Katalin Madarasi, Dóra Kis, Viktor Ozohanics, Olivér Papp, Ildikó Kovács, Péter Lubec, Gert Dobolyi, Árpád Kardos, József Drahos, László Juhász, Gábor Kékesi, Katalin A |
| description | Highlights • First study examining synaptic proteome changes due to prenatal immune activation. • Presynaptic molecular mechanisms are more affected than postsynaptic ones. • Several basic and synaptic cellular functions are influenced. • Camk2a is downregulated in the prefrontal cortex. • Our data show widespread overlap with schizophrenia- and autism-related molecules. |
| doi_str_mv | 10.1016/j.bbi.2016.04.002 |
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| ispartof | Brain, behavior, and immunity, 2016-08, Vol.56, p.289-309 |
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| subjects | Allergy and Immunology Animals Autism spectrum disorder (ASD) Autism Spectrum Disorder - etiology Cerebral cortex Disease Models, Animal Female Lipopolysaccharides - pharmacology Male Maternal immune activation (MIA) Neuroproteomics Prefrontal Cortex - metabolism Pregnancy Prenatal Exposure Delayed Effects - immunology Prenatal Exposure Delayed Effects - metabolism Proteome - metabolism Proteomics - methods Psychiatry Rats Rats, Wistar Schizophrenia Schizophrenia - etiology Synapses - metabolism Synapses - pathology Synaptosome Synaptosomes - metabolism Synaptosomes - pathology |
| title | Widespread alterations in the synaptic proteome of the adolescent cerebral cortex following prenatal immune activation in rats |
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