Widespread alterations in the synaptic proteome of the adolescent cerebral cortex following prenatal immune activation in rats

Highlights • First study examining synaptic proteome changes due to prenatal immune activation. • Presynaptic molecular mechanisms are more affected than postsynaptic ones. • Several basic and synaptic cellular functions are influenced. • Camk2a is downregulated in the prefrontal cortex. • Our data...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-08, Vol.56, p.289-309
Hauptverfasser:	Györffy, Balázs A, Gulyássy, Péter, Gellén, Barbara, Völgyi, Katalin, Madarasi, Dóra, Kis, Viktor, Ozohanics, Olivér, Papp, Ildikó, Kovács, Péter, Lubec, Gert, Dobolyi, Árpád, Kardos, József, Drahos, László, Juhász, Gábor, Kékesi, Katalin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Autism spectrum disorder (ASD) Autism Spectrum Disorder - etiology Cerebral cortex Disease Models, Animal Female Lipopolysaccharides - pharmacology Male Maternal immune activation (MIA) Neuroproteomics Prefrontal Cortex - metabolism Pregnancy Prenatal Exposure Delayed Effects - immunology Prenatal Exposure Delayed Effects - metabolism Proteome - metabolism Proteomics - methods Psychiatry Rats Rats, Wistar Schizophrenia Schizophrenia - etiology Synapses - metabolism Synapses - pathology Synaptosome Synaptosomes - metabolism Synaptosomes - pathology
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Zusammenfassung:	Highlights • First study examining synaptic proteome changes due to prenatal immune activation. • Presynaptic molecular mechanisms are more affected than postsynaptic ones. • Several basic and synaptic cellular functions are influenced. • Camk2a is downregulated in the prefrontal cortex. • Our data show widespread overlap with schizophrenia- and autism-related molecules.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.04.002