Arginase-1 is Expressed Exclusively by Infiltrating Myeloid Cells in CNS Injury and Disease

Highlights • Arginase-1 is expressed exclusively in infiltrating myeloid cells and not microglia in SCI and EAE. • LysM-EGFP mouse is a good model to distinguish between infiltrating myeloid cells and microglia in CNS injury and disease. • Factors in the CNS environment prevent Arginase-1 expression...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-08, Vol.56, p.61-67
Hauptverfasser:	Greenhalgh, Andrew D, Passos dos Santos, Rosmarini, Zarruk, Juan Guillermo, Salmon, Christopher K, Kroner, Antje, David, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Arginase - metabolism Arginase-1 CNS injury Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - metabolism Female Green Fluorescent Proteins Inflammation Inflammation - metabolism LysM-EGFP Macrophages Mice Mice, Inbred C57BL Microglia Microglia - metabolism Muramidase Myeloid Cells - metabolism Psychiatry Spinal Cord Injuries - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Arginase-1 is expressed exclusively in infiltrating myeloid cells and not microglia in SCI and EAE. • LysM-EGFP mouse is a good model to distinguish between infiltrating myeloid cells and microglia in CNS injury and disease. • Factors in the CNS environment prevent Arginase-1 expression in microglia during inflammation.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.04.013