Harnessing Fc receptor biology in the design of therapeutic antibodies

Highlights • The antibody Fc domain engages immune-activating, inhibitory, and homeostatic Fc receptors. • Fc domains are largely unaltered in existing therapeutic antibodies, whether to promote or to avoid Fc receptor recruitment. • Recent advances in Fc biology have enabled new antibody and Fc fus...

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Veröffentlicht in:	Current opinion in immunology 2016-06, Vol.40, p.78-87
Hauptverfasser:	Sondermann, Peter, Szymkowski, David E
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Monoclonal - therapeutic use Drug Design Humans Immunoglobulin Fc Fragments - therapeutic use Immunotherapy - methods Immunotherapy - trends Protein Engineering Receptors, Fc - genetics Receptors, Fc - metabolism Recombinant Fusion Proteins - therapeutic use Signal Transduction
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Beschreibung
Zusammenfassung:	Highlights • The antibody Fc domain engages immune-activating, inhibitory, and homeostatic Fc receptors. • Fc domains are largely unaltered in existing therapeutic antibodies, whether to promote or to avoid Fc receptor recruitment. • Recent advances in Fc biology have enabled new antibody and Fc fusion design strategies. • Fc engineering facilitates functional optimization of antibodies for the desired clinical indication.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2016.03.005