Endoplasmic reticulum stress induces 5-fluorouracil resistance in human colon cancer cells

Highlights • 5-FU–resistant colon cancer cell expressed higher level of ER stress–related proteins. • It exhibited intense ER staining and mitochondrial Ca2+ overload. • 5-FU resistance is associated with ER stress in colon cancer

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Veröffentlicht in:	Environmental toxicology and pharmacology 2016-06, Vol.44, p.128-133
Hauptverfasser:	Kim, Joon Ki, Kang, Kyoung Ah, Piao, Mei Jing, Ryu, Yea Seong, Han, Xia, Fernando, Pattage Madushan Dilhara Jayatissa, Oh, Min Chang, Park, Jeong Eon, Shilnikova, Kristina, Boo, Sun Jin, Na, Soo-Young, Jeong, Yong Joo, Jeong, Seung Uk, Hyun, Jin Won
Format:	Artikel
Sprache:	eng
Schlagworte:	5-FU resistance Activating Transcription Factor 6 - genetics Antimetabolites, Antineoplastic - pharmacology Calcium - metabolism Cell Line, Tumor Cell Survival - drug effects Colonic Neoplasms - metabolism Drug Resistance, Neoplasm Emergency Endoplasmic Reticulum Stress ER stress ER stress-related proteins Extracellular signal-regulated kinases Extracellular Signal-Regulated MAP Kinases - genetics Fluorouracil - pharmacology Gene Knockdown Techniques Heat-Shock Proteins - genetics Human colon cancer cells Humans Mitochondria - metabolism Proto-Oncogene Proteins c-akt - genetics RNA, Small Interfering - genetics
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Zusammenfassung:	Highlights • 5-FU–resistant colon cancer cell expressed higher level of ER stress–related proteins. • It exhibited intense ER staining and mitochondrial Ca2+ overload. • 5-FU resistance is associated with ER stress in colon cancer
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2016.05.005