In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model
[Display omitted] The in vitro efficacy of poloxamer 407-based formulations with antifungal ciclopirox olamine has been analysed in an infected nail plate model. As artificial nail plates, keratin films made of human hair keratin and slices from bovine hooves have been utilised. Several poloxamer 40...
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| Veröffentlicht in: | International journal of pharmaceutics 2016-05, Vol.505 (1-2), p.20-23 |
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| container_title | International journal of pharmaceutics |
| container_volume | 505 |
| creator | Taeuber, Anja Mueller-Goymann, Christel C |
| description | [Display omitted]
The in vitro efficacy of poloxamer 407-based formulations with antifungal ciclopirox olamine has been analysed in an infected nail plate model. As artificial nail plates, keratin films made of human hair keratin and slices from bovine hooves have been utilised. Several poloxamer 407-based formulations with 1 % active ingredient indicated complete growth inhibition of the dermatophyte fungus Trichophyton rubrum after 6days of incubation. |
| doi_str_mv | 10.1016/j.ijpharm.2016.01.082 |
| format | Article |
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The in vitro efficacy of poloxamer 407-based formulations with antifungal ciclopirox olamine has been analysed in an infected nail plate model. As artificial nail plates, keratin films made of human hair keratin and slices from bovine hooves have been utilised. Several poloxamer 407-based formulations with 1 % active ingredient indicated complete growth inhibition of the dermatophyte fungus Trichophyton rubrum after 6days of incubation.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2016.01.082</identifier><identifier>PMID: 26992819</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Topical ; Animals ; Antifungal Agents - administration & dosage ; Antifungal Agents - pharmacology ; Cattle ; Chemistry, Pharmaceutical ; Ciclopirox olamine ; Humans ; In Vitro Techniques ; Keratin film ; Onychomycosis ; Onychomycosis - drug therapy ; Poloxamer - chemistry ; Poloxamer 407 ; Pyridones - administration & dosage ; Pyridones - pharmacology ; Tinea - drug therapy ; Treatment Outcome ; Trichophyton - drug effects ; Trichophyton rubrum</subject><ispartof>International journal of pharmaceutics, 2016-05, Vol.505 (1-2), p.20-23</ispartof><rights>2016</rights><rights>Copyright © 2016. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-e7537a363d5e2b5312e833175c5f7804f085348b675b2af4acb8190f2580b6c13</citedby><cites>FETCH-LOGICAL-c398t-e7537a363d5e2b5312e833175c5f7804f085348b675b2af4acb8190f2580b6c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2016.01.082$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26992819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taeuber, Anja</creatorcontrib><creatorcontrib>Mueller-Goymann, Christel C</creatorcontrib><title>In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
The in vitro efficacy of poloxamer 407-based formulations with antifungal ciclopirox olamine has been analysed in an infected nail plate model. As artificial nail plates, keratin films made of human hair keratin and slices from bovine hooves have been utilised. Several poloxamer 407-based formulations with 1 % active ingredient indicated complete growth inhibition of the dermatophyte fungus Trichophyton rubrum after 6days of incubation.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Antifungal Agents - pharmacology</subject><subject>Cattle</subject><subject>Chemistry, Pharmaceutical</subject><subject>Ciclopirox olamine</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Keratin film</subject><subject>Onychomycosis</subject><subject>Onychomycosis - drug therapy</subject><subject>Poloxamer - chemistry</subject><subject>Poloxamer 407</subject><subject>Pyridones - administration & dosage</subject><subject>Pyridones - pharmacology</subject><subject>Tinea - drug therapy</subject><subject>Treatment Outcome</subject><subject>Trichophyton - drug effects</subject><subject>Trichophyton rubrum</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuO1DAQRS0EYpqBTwB5ySbBj_iRFUKjeUkjsYG15Thlxi0nDnbSYv4eN93DFjYuWffeKlUdhN5T0lJC5ad9G_bLo81Ty-q3JbQlmr1AO6oVb3in5Eu0I1zpRlDFL9CbUvaEEMkof40umOx7pmm_Q_l-xoew5oThYONm15BmnDxeHwHbeQ1-m3_YiMH74Kx7OkpLiumXnSDjjqhmsAVG7FOetvgnXXCYa7S-HtxatdmGiJcqAp7SCPEteuVtLPDuXC_R95vrb1d3zcPX2_urLw-N471eG1CCK8slHwWwQXDKQHNOlXDCK006T7TgnR6kEgOzvrNuqBsRz4Qmg3SUX6KPp75LTj83KKuZQnEQo50hbcVQTbTsO0H_w6q06rmWuq9WcbK6nErJ4M2Sw2Tzk6HEHMmYvTmTMUcyhlBTydTch_OIbZhg_Jt6RlENn08GqDc5BMimuACzgzHkekgzpvCPEb8BndChjw</recordid><startdate>20160530</startdate><enddate>20160530</enddate><creator>Taeuber, Anja</creator><creator>Mueller-Goymann, Christel C</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20160530</creationdate><title>In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model</title><author>Taeuber, Anja ; Mueller-Goymann, Christel C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-e7537a363d5e2b5312e833175c5f7804f085348b675b2af4acb8190f2580b6c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Topical</topic><topic>Animals</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Antifungal Agents - pharmacology</topic><topic>Cattle</topic><topic>Chemistry, Pharmaceutical</topic><topic>Ciclopirox olamine</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Keratin film</topic><topic>Onychomycosis</topic><topic>Onychomycosis - drug therapy</topic><topic>Poloxamer - chemistry</topic><topic>Poloxamer 407</topic><topic>Pyridones - administration & dosage</topic><topic>Pyridones - pharmacology</topic><topic>Tinea - drug therapy</topic><topic>Treatment Outcome</topic><topic>Trichophyton - drug effects</topic><topic>Trichophyton rubrum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taeuber, Anja</creatorcontrib><creatorcontrib>Mueller-Goymann, Christel C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taeuber, Anja</au><au>Mueller-Goymann, Christel C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2016-05-30</date><risdate>2016</risdate><volume>505</volume><issue>1-2</issue><spage>20</spage><epage>23</epage><pages>20-23</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
The in vitro efficacy of poloxamer 407-based formulations with antifungal ciclopirox olamine has been analysed in an infected nail plate model. As artificial nail plates, keratin films made of human hair keratin and slices from bovine hooves have been utilised. Several poloxamer 407-based formulations with 1 % active ingredient indicated complete growth inhibition of the dermatophyte fungus Trichophyton rubrum after 6days of incubation.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26992819</pmid><doi>10.1016/j.ijpharm.2016.01.082</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2016-05, Vol.505 (1-2), p.20-23 |
| issn | 0378-5173 1873-3476 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Topical Animals Antifungal Agents - administration & dosage Antifungal Agents - pharmacology Cattle Chemistry, Pharmaceutical Ciclopirox olamine Humans In Vitro Techniques Keratin film Onychomycosis Onychomycosis - drug therapy Poloxamer - chemistry Poloxamer 407 Pyridones - administration & dosage Pyridones - pharmacology Tinea - drug therapy Treatment Outcome Trichophyton - drug effects Trichophyton rubrum |
| title | In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model |
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