In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model

[Display omitted] The in vitro efficacy of poloxamer 407-based formulations with antifungal ciclopirox olamine has been analysed in an infected nail plate model. As artificial nail plates, keratin films made of human hair keratin and slices from bovine hooves have been utilised. Several poloxamer 40...

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Veröffentlicht in:	International journal of pharmaceutics 2016-05, Vol.505 (1-2), p.20-23
Hauptverfasser:	Taeuber, Anja, Mueller-Goymann, Christel C
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Antifungal Agents - administration & dosage Antifungal Agents - pharmacology Cattle Chemistry, Pharmaceutical Ciclopirox olamine Humans In Vitro Techniques Keratin film Onychomycosis Onychomycosis - drug therapy Poloxamer - chemistry Poloxamer 407 Pyridones - administration & dosage Pyridones - pharmacology Tinea - drug therapy Treatment Outcome Trichophyton - drug effects Trichophyton rubrum
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Zusammenfassung:	[Display omitted] The in vitro efficacy of poloxamer 407-based formulations with antifungal ciclopirox olamine has been analysed in an infected nail plate model. As artificial nail plates, keratin films made of human hair keratin and slices from bovine hooves have been utilised. Several poloxamer 407-based formulations with 1 % active ingredient indicated complete growth inhibition of the dermatophyte fungus Trichophyton rubrum after 6days of incubation.
ISSN:	0378-5173 1873-3476
DOI:	10.1016/j.ijpharm.2016.01.082